Our research program primarily focuses on the use of electron microscopic techniques to acquire and analyze high resolution structures of molecules, cells and tissues in 3-D at the highest possible resolutions. The CCR is the NCI’s internal, federally funded cancer center where world leading physician-scientists are working on the cutting edge of medicine, developing clinical trials of new, sometimes first-in-human drugs and new treatment approaches. The overall goal of the Center for Molecular Microscopy is to apply emerging technologies in 3-D electron microscopy to problems of fundamental interest in cancer and HIV/AIDS. Work carried out by the CMM is supported by instrumentation at the Advanced Technology Research Facility in Frederick, MD. In the technology development component, we pursue innovations in high-resolution imaging and volume EM approaches to expand the technological toolkit and open new avenues for future research. The Collaboratory is overseen by the CMM Advisory Panel, appointed by NCI leadership. Its mission is to manage and assess molecular interaction data obtained through multiple platforms, increase the understanding of the effect of those interactions on the. This component of the CMM is designed to use emerging tools in 3-D electron microscopy to undertake biological research relevant to the NCI/NIH mission. The Genomic and Pharmacology Facility falls within the National Cancer Institutes (NCI) Center for Cancer Research (CCR), within the Developmental Therapeutics Branch. At the Center for Molecular Microscopy (CMM), we develop and utilize new techniques and emerging technologies for high resolution 3-D electron microscopy in structural biology (high resolution imaging) and cell biology (volume EM).ĬMM is divided into two distinct components: In the Collaboratory, NCI researchers can work with us on important problems that are well-suited to our capabilities.